Fantasy matchup analysis — how many points the 49ers allow to quarterbacks. Updated through the 2025 season. Use this to identify streamers and make start/sit decisions.
Players who have historically scored most against the San Francisco 49ers defense:
Last 10 games quarterbacks faced the San Francisco 49ers (2024–2025 seasons):
| Game | Player | Fantasy Pts |
|---|---|---|
| S2026 Wk7 | Michael Penix Jr. ATL |
20.4 |
| S2026 Wk6 | Jayden Daniels WAS |
21 |
| S2026 Wk5 | Sam Darnold SEA |
10.3 |
| S2026 Wk4 | Bo Nix DEN |
13.6 |
| S2026 Wk2 | Malik Willis MIA |
12.5 |
| S2026 Wk1 | Stetson Bennett LAR |
1.4 |
| S2026 Wk1 | Matthew Stafford LAR |
5.1 |
| S2025 Wk18 | Sam Darnold SEA |
8.8 |
| S2025 Wk17 | Caleb Williams CHI |
23 |
| S2025 Wk16 | Philip Rivers UNK |
18.1 |
This is matchup context, not a personalized recommendation. Connect your Sleeper, ESPN, or Yahoo league and PlayCaller's AI gives you a start/sit decision based on your exact roster, league scoring, and this week's matchup.
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