Fantasy matchup analysis — how many points the 49ers allow to running backs. Updated through the 2025 season. Use this to identify streamers and make start/sit decisions.
Players who have historically scored most against the San Francisco 49ers defense:
Last 10 games running backs faced the San Francisco 49ers (2024–2025 seasons):
| Game | Player | Fantasy Pts |
|---|---|---|
| S2026 Wk7 | Khalil Herbert ATL |
3.8 |
| S2026 Wk7 | Bijan Robinson ATL |
17.2 |
| S2026 Wk6 | Austin Ekeler WAS |
2.7 |
| S2026 Wk6 | Jeremy McNichols WAS |
1.3 |
| S2026 Wk6 | Rachaad White WAS |
15.7 |
| S2026 Wk5 | Emanuel Wilson SEA |
13.2 |
| S2026 Wk5 | George Holani SEA |
5.1 |
| S2026 Wk4 | J.K. Dobbins DEN |
7.2 |
| S2026 Wk4 | Tyler Badie DEN |
7.9 |
| S2026 Wk4 | RJ Harvey DEN |
19.3 |
This is matchup context, not a personalized recommendation. Connect your Sleeper, ESPN, or Yahoo league and PlayCaller's AI gives you a start/sit decision based on your exact roster, league scoring, and this week's matchup.
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