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NFL · Defense vs Position · 2026

Buffalo Bills Defense vs Flex (RB/WR/TE)

Fantasy matchup analysis — how many points the Bills allow to flex (rb/wr/te). Updated through the 2025 season. Use this to identify streamers and make start/sit decisions.

9.4
Avg fantasy pts allowed per game to flex (rb/wr/te)
#1 Easiest (Top 5)
NFL defense ranking vs FLEX
284
Games in sample (2024–2025)

Top Targets vs Bills

Players who have historically scored most against the Buffalo Bills defense:

#1 Target 🎯
Puka Nacua
LAR
39.8
avg pts vs Bills (2 games)
#2 Target
Amon-Ra St. Brown
DET
36.3
avg pts vs Bills (2 games)
#3 Target
Derrick Henry
BAL
32.6
avg pts vs Bills (2 games)

Recent Game Log

Last 10 games flex (rb/wr/te) faced the Buffalo Bills (2024–2025 seasons):

GamePlayerFantasy Pts
S2026 Wk8 Mark Andrews
BAL
4.4
S2026 Wk8 Rashod Bateman
BAL
3.2
S2026 Wk8 Ja'Kobi Lane
BAL
2.3
S2026 Wk8 Josh Cuevas
BAL
2.5
S2026 Wk6 Michael Mayer
LV
16.5
S2026 Wk6 Tre Tucker
LV
26.7
S2026 Wk6 Mike Washington Jr.
LV
6
S2026 Wk6 Brock Bowers
LV
11
S2026 Wk6 Ashton Jeanty
LV
15.8
S2026 Wk6 Jalen Nailor
LV
1.9

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Frequently Asked Questions

Is the Buffalo Bills defense good or bad for fantasy flex (rb/wr/te)?
The Buffalo Bills allow an average of 9.4 fantasy points per game to flex (rb/wr/te), ranking #1 Easiest (Top 5) among all NFL defenses (284 games sampled, 2024–2025 seasons).
Which flex (rb/wr/te) should I start against the Buffalo Bills?
Historically, flex (rb/wr/te) who have scored most against the Buffalo Bills: Puka Nacua (39.8 avg pts in 2 games), Amon-Ra St. Brown (36.3 avg pts in 2 games), Derrick Henry (32.6 avg pts in 2 games). Connect your league to PlayCaller for a roster-specific verdict.
How do I use defense vs position data in fantasy football?
Defense vs position (DVP) data shows how many fantasy points a team has historically allowed to a specific position. High avg pts allowed = easy matchup. Low avg pts allowed = tough matchup. Use it as a tiebreaker when deciding between two similarly-ranked players with different matchups.

Other positions vs Bills

Running BacksWide ReceiversTight EndsQuarterbacksKickers

NFL position rankings

RB Rankings WR Rankings TE Rankings QB Rankings