As of August 17, 2026, the NFL offseason is in full swing with preseason games underway and teams making critical roster decisions before the regular season kicks off. For fantasy managers focused on roster construction, the latest injury reports and depth-chart developments are just as important as any NFL free agency move made this spring. From Buffalo to Arizona, several key players are dealing with preseason setbacks that could reshape how you approach your drafts and keeper decisions heading into the fall.